Unbalanced Multilateralism should be considered as a part of the West World’s strategic policy to confine Iran’s economic and international capabilities. Indications of unbalanced multilateralism in Iran’s economic sanction policymaking are focused on executive mechanisms and America and EU’s legislative bodies. Although America and EU have relatively identical strategic objectives toward Islamic Republic of Iran, Iran’s economic sanction pattern has an unbalanced nature. The most severe sanctions were in 2011, which were called “crippling sanctions”. The crippling sanctions mainly targeted financial system of Islamic Republic of Iran and imposed various restrictions on Iran’s economic structure. Restrictions on selling oil to other countries and the ones on receiving financial sources caused by economic transactions should be considered as indications of Iran’s economic sanction.Trends to reduce Iran’s economic sanctions have started since 24 November 2013 and they are subject to the measures that control strategic, technical and industrial capabilities of Iran within nuclear field. Although some sanctions were reduced within this period, restricting trends of Iran’s capabilities in the unbalanced multilateralism atmosphere of the great powers have been continued. The process of imposing restriction and reducing reduction of some sanctions in a phased manner show that America, EU and Russia have taken advantage of unbalanced multilateralism strategy toward Iran.