When neo-conservative came to power, they acquired twofold behavioral models towards nuclear case of Iran. Mainly, this derives of essential conflicts of the two state, and partly, because of differential regional and international interests and favorites of U.S. and Islamic Republic of Iran. With studying Iranian nuclear viewpoints, we analyze the mentioned American strategy and tactics, with historical analytic approach. For this, it would be considered possible choices and executed approaches in both of behavior change and regime change. At last, structural international and regional obstacles of American foreign policy, we considered, using fragile deterrence choice as favored approach will be suggested.